Ribonucleotide Reductase Inhibition: Regulation of the Radiosensitive Phenotype via NFkB and Bcl-2
نویسندگان
چکیده
منابع مشابه
Unique ATP - cone - driven allosteric regulation of ribonucleotide 1 reductase via the radical - generating subunit 2
15 Ribonucleotide reductases (RNRs) are key enzymes in DNA synthesis and repair, with 16 sophisticated allosteric mechanisms controlling both substrate specificity and overall activity. 17 In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the 18 catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, 19 we discovered ATP-cones ...
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suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
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Balanced deoxyribonucleotides pools are essential for cell survival and genome stability. Ribonucleotide reductase is the rate-limiting enzyme for the production of deoxyribonucleotides. We report here that p53 suppresses ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2) via inhibiting mammalian target of rapamycin complex 1 (mTORC1). In vitro, cancer cell lines and mouse embryonic fibrobl...
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Enzymes catalyze many biological reactions. The rates of chemical reaction in the presence ofenzymes are, in some cases, accelerated more than 10 orders of magnitude relative to thecorresponding rates in solution.In this paper a comparison between optimized structures of two enzyme molecules in aspect ofenergy and dipole moment in different conditions including presence of metallic ion, without...
متن کاملNovel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical-generating subunit. The ATP-c...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2002
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.1.5.175